As soon as you leave the airport area, get onto the N2 towards Somerset West. Then take the turnoff onto the R300 towards Bellville. After approximately 10km turn onto the N1 towards Cape Town and take Exit Willie van Schoor Road (R302 North).
Turn right towards Durbanville. Stay on this road for approximately 5 km. You will pass Tygervalley Shopping Centre, one Engen Garage and the Rose Garden. After you have passed the Rose Garden and the second Engen Garage move into the right lane, pass over 2 sets of traffic lights, then turn right at the next (3rd) set into Van der Byl Road. Follow the road until you see the Mackenzie's Guesthouse Sign on the left.